Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.
نویسندگان
چکیده
The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 9 شماره
صفحات -
تاریخ انتشار 2010